Work

Muscle function decline and mitochondria changes in middle age precede sarcopenia in mice

Year: 2018

Type: article

Abstract: resting levels were reduced at age 10-14 months and significantly increased in the Older group. This was consistent with a reduced number of mitochondria-to-jSR pairs in the Older group compared to the Juvenile. Our results support the idea of several age-dependent changes in mitochondria that are accentuated in midlife prior to a complete sarcopenic phenotype.

Source: Aging

DOI: 10.18632/aging.101358

Authors: Andrea del Campo, Ignacio Contreras-Hernández, Mauricio Castro-Sepúlveda, Cristian A. Campos, Reinaldo Figueroa, María Florencia Tevy, Verónica Eisner, Mariana Casas, Enrique Jaimovich

Institutions: University of Chile, Pontificia Universidad Católica de Chile, Universidad Mayor

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Pontificia Universidad Católica de Chile

OpenAlex ID: W2782197946

FWCI: 3.278

Cites: 59

Cited by: 116

Related to: 10