Work

SLE-Associated Defects Promote Altered T Cell Function

Year: 2017

Type: article

Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease linked to profound defects in the function and phenotype of T lymphocytes. Here, we describe abnormal signaling pathways that have been documented in T cells from patients with SLE and discuss how they impact gene expression and immune function, in order to understand how they contribute to disease development and progression.

Source: Critical Reviews in Immunology

DOI: 10.1615/critrevimmunol.2018025213

Authors: Jose C. Crispin, Christian M. Hedrich, Abel Suárez-Fueyo, Denis Comte, George C. Tsokos