Dexmedetomidine as an Oral Premedication to Facilitate Mask Induction for General Anesthesia for Pediatric Dentistry
Year: 2014
Type: dissertation
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Dexmedetomidine is a relatively new alpha-2 agonist sedative agent that has many beneficial properties of a premedication. In this randomized clinical trial, oral dexmedetomidine was compared to oral midazolam for its efficacy in gaining cooperation for mask acceptance for induction of general anesthesia. Study subjects consisted of 28 children aged between 3-8 years and ASA I-II status who demonstrated poor cooperation at a prior dental appointment that were randomized to receive either dexmedetomidine 6 micrograms/kg or midazolam 0.7mg/kg 15 minutes prior to induction of anesthesia. The midazolam group had a significantly greater level of sedation but there was no significant difference in cooperation behavior during induction. No differences were found in time to discharge and there were no cases of hypotension and bradycardia requiring treatment. Under the context used in this study, oral dexmedetomidine can be a viable alternative oral premedication to midazolam prior to induction of GA.
Source: TSpace (University of Toronto)
Author: Joonyoung Ji
Language: English
Subfield: Anesthesiology and Pain Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2782615227