Work

An Intracellular Ammonium Transporter Is Necessary for Replication, Differentiation, and Resistance to Starvation and Osmotic Stress in Trypanosoma cruzi

Year: 2018

Type: article

Abstract: Trypanosoma cruzi is an important human and animal pathogen and the etiologic agent of Chagas disease. The parasite undergoes drastic changes in its metabolism during its life cycle. Amino acid consumption becomes important in the infective stages and leads to the production of ammonia (NH 3 ), which needs to be detoxified. We report here the identification of an ammonium (NH 4 + ) transporter that localizes to acidic compartments and is important for replication, differentiation, and resistance to starvation and osmotic stress.

Source: mSphere

DOI: 10.1128/msphere.00377-17

Authors: Teresa Cruz-Bustos, Evgeniy Potapenko, Melissa Storey, Roberto Docampo

Institution: University of Georgia

Language: English

Topic: Trypanosoma species research and implications

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $3,500

Funders: University of Georgia, National Institute of Allergy and Infectious Diseases