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Differential Ability of Pandemic and Seasonal H1N1 Influenza A Viruses To Alter the Function of Human Neutrophils

Year: 2018
Type: article
Abstract: A long-standing notion is that IAV inhibits normal neutrophil function and thereby predisposes individuals to secondary bacterial infections. Here we report that seasonal H1N1 IAV primes human neutrophils for enhanced killing of Staphylococcus aureus . Moreover, we provide a comprehensive view of the changes in neutrophil gene expression during interaction with seasonal or pandemic IAV and report how these changes relate to functions such as bactericidal activity. This study expands our knowledge of IAV interactions with human neutrophils.
Source: mSphere
DOI: 10.1128/mspheredirect.00567-17
Authors: Natalia Malachowa, Brett Freedman, Daniel E. Sturdevant, Scott D. Kobayashi, Vinod Nair, Friederike Feldmann, Tregei Starr, Olivia Steele-Mortimer, John C. Kash, Jeffery K. Taubenberger, Heinz Feldmann, Frank R. DeLeo
Language: English
Subfield: Epidemiology
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,500
OpenAlex ID: W2782799749
FWCI: 1.952
Cites: 59
Cited by: 12
Related to: 10