Work

Cobalt‐Catalyzed Coupling of Benzoic Acid C−H Bonds with Alkynes, Styrenes, and 1,3‐Dienes

Year: 2018

Type: article

Abstract: A method for cobalt‐catalyzed, carboxylate‐directed functionalization of arene C−H bonds is reported. Alkynes, styrenes, and 1,3‐dienes can be coupled with benzoic acids to provide cyclic products in good yields. The reactions proceed in the presence of a cobalt(II) hexafluoroacetylacetonate catalyst, (TMS)2NH base, Ce(SO4)2 cooxidant, and oxygen oxidant.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201711968

Authors: Tung Thanh Nguyen, Liene Grigorjeva, Olafs Daugulis

Institution: University of Houston

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Welch Foundation, National Institute of General Medical Sciences

Award: New Methods for Direct Carbon-Hydrogen Bond Functionalization