Work

Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa

Year: 2018

Type: article

Abstract: secretes 2-heptyl-3-hydroxy-4-quinolone (PQS), a quorum sensing (QS) signal that regulates the expression of numerous virulence genes. Here we report the development and application of chemical probes to globally map quinolone binding proteins. The revealed quinolone interactome contains both known as well as newly identified virulence factors and presents new targets for the treatment of bacterial infections.

Source: Chemical Science

DOI: 10.1039/c7sc04287f

Authors: Rambabu Dandela, Danielle Mantin, Benjamin F. Cravatt, Josep Rayo, Michael M. Meijler

Institutions: Ben-Gurion University of the Negev, Scripps Research Institute

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Universiteit Leiden, United States-Israel Binational Science Foundation, H2020 European Research Council, FP7 Ideas: European Research Council