Work

Posttranslational Modifications of RAS Proteins

Year: 2018

Type: preprint

Abstract: genes encode four proteins that play central roles in oncogenesis by acting as binary molecular switches that regulate signaling pathways for growth and differentiation. Each is subject to a set of posttranslational modifications (PTMs) that modify their activity or are required for membrane targeting. The enzymes that catalyze the various PTMs are potential targets for anti-RAS drug discovery. The PTMs of RAS proteins are the focus of this review.

Source: Cold Spring Harbor Perspectives in Medicine

DOI: 10.1101/cshperspect.a031484

Authors: Ian Ahearn, Mo Zhou, Mark R. Philips

Institutions: NYU Langone’s Laura and Isaac Perlmutter Cancer Center, New York University

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Cancer Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases