Work

Proliferation and differentiation of human fetal brain neural stem cells in vitro

Year: 2018

Type: article

Abstract: : Primary human fetal brain neural stem cells (hNSCs) are a unique non-genetically modified model system to study molecular mechanisms underlying human neural development, to model human diseases, and to screen drugs or validate new treatments. They may also be used for cell transplantation to treat various neurological diseases. This protocol details our methods that can be used to expand hNSCs in culture as well as how to differentiate them into various neuronal lineages and astrocytes. Keywords: neural stem cell, proliferation, differentiation, neuron, astrocyte

Source: Journal of Neurorestoratology

DOI: 10.2147/jn.s148794

Authors: Erica McGrath, Junling Gao, Ping Wu

Institutions: The University of Texas Medical Branch at Galveston, Capital Medical University, Beijing Institute for Brain Disorders

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,700