Work

Enhanced Efflux Pump Activity in Old Candida glabrata Cells

Year: 2018

Type: article

Abstract: ABSTRACT We investigated the effect of replicative aging on antifungal resistance in Candida glabrata . Our studies demonstrate significantly increased transcription of ABC transporters and efflux pump activity in old versus young C. glabrata cells of a fluconazole-sensitive and -resistant strain. In addition, higher tolerance to killing by micafungin and amphotericin B was noted and is associated with higher transcription of glucan synthase gene FKS1 and lower ergosterol content in older cells.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.02227-17

Authors: Somanon Bhattacharya, Bettina C. Fries

Institution: Stony Brook University

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases