Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism
Work
Year: 2018
Type: article
Abstract: Altered glycolytic flux in cancer cells (the "Warburg effect") causes their proliferation to rely upon elevated glutamine metabolism ("glutamine addiction"). This requirement is met by the overexpress... more
Source: Journal of Biological Chemistry
Cites: 48
Cited by: 79
Related to: 10
FWCI: 3.784
Citation percentile (by year/subfield): 81.81
Subfield: Cancer Research
Domain: Life Sciences
Sustainable Development Goal Good health and well-being
Open Access status: hybrid
APC paid (est): $2,500
Funders Directorate for Biological Sciences, National Cancer Institute, National Institute of General Medical Sciences, National Institute of General Medical Sciences, National Institute of General Medical Sciences
Grant IDS DMR-1332208, CA210184, GM103485, GM122575, GM040654