Fibrin turnover and pleural organization: bench to bedside
Year: 2018
Type: review
Abstract: Recent studies have shed new light on the role of the fibrinolytic system in the pathogenesis of pleural organization, including the mechanisms by which the system regulates mesenchymal transition of mesothelial cells and how that process affects outcomes of pleural injury. The key contribution of plasminogen activator inhibitor-1 to the outcomes of pleural injury is now better understood as is its role in the regulation of intrapleural fibrinolytic therapy. In addition, the mechanisms by which fibrinolysins are processed after intrapleural administration have now been elucidated, informing new candidate diagnostics and therapeutics for pleural loculation and failed drainage. The emergence of new potential interventional targets offers the potential for the development of new and more effective therapeutic candidates.
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Institute for Health and Care Research, Marie Curie, New South Wales Workers' Compensation Dust Disease Board, Department of Health and Aged Care, Australian Government, National Institutes of Health, National Health and Medical Research Council, Cancer Council Western Australia, National Heart, Lung, and Blood Institute, National Institute of Environmental Health Sciences
Awards: G1467967680, G2873602211, G3287507429, Single chain urokinase plasminogen activator (scuPA) for treatment of loculated complicated parapneumonic effusions and empyema, G46760119, G4998711640, The Randomised Ambulatory Management of Primary Pneumothorax Study (RAMPP) - Ambulatory chest catheter drainage devices (Pneumovent) in the treatment of primary pneumothorax – randomised trial to assess early discharge and outpatient management, Delivery of PAI-1-targeted intrapleural fibrinolytic therapy for empyema, G5297681709, Amelioration of Mitochondrial Dysfunction by Thioredoxin in Hyperoxia, Development of antidotes for toxic gases, The role of coagulation cascade proteases in pleural fibrosis, G8935812199
OpenAlex ID: W2783409181