Association between Vitamin D Genetic Risk Score and Cancer Risk in a Large Cohort of U.S. Women
Year: 2018
Type: article
Study design: Observational Study
Abstract: Some observational studies suggest an inverse association between circulating 25-hydroxyvitamin D (25OHD) and cancer incidence and mortality. We conducted a Mendelian randomization analysis of the relationship between a vitamin D genetic risk score (GRS, range 0–10), comprised of five single nucleotide polymorphisms (SNPs) of vitamin D status in the DHCR7, CYP2R1 and GC genes and cancer risk among women. Analysis was performed in the Women’s Genome Health Study (WGHS), including 23,294 women of European ancestry who were cancer-free at baseline and followed for 20 years for incident cancer. In a subgroup of 1782 WGHS participants with 25OHD measures at baseline, the GRS was associated with circulating 25OHD mean (SD) = 67.8 (26.1) nmol/L, 56.9 (18.7) nmol/L in the lowest versus 73.2 (27.9) nmol/L in the highest quintile of the GRS (p trend < 0.0001 across quintiles). However, in age-adjusted Cox proportional hazards models, higher GRS (reflecting higher 25OHD levels) was not associated (cases; Hazard Ratio (HR) (95% Confidence Interval (CI)), p-value) with incident total cancer: (n = 3985; 1.01 (1.00–1.03), p = 0.17), breast (n = 1560; 1.02 (0.99–1.05), p = 0.21), colorectal (n = 329; 1.06 (1.00–1.13), p = 0.07), lung (n = 330; 1.00 (0.94–1.06), p = 0.89) or total cancer death (n = 770; 1.00 (0.96–1.04), p = 0.90). Results were similar in fully-adjusted models. A GRS for higher circulating 25OHD was not associated with cancer incidence or mortality.
Source: Nutrients
DOI: 10.3390/nu10010055
Institutions: Brigham and Women's Hospital, Harvard University
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,499
Awards: Women's Health Study: Continued Follow-Up, G229684361, Circulating Vitamin D Levels and Risk of Breast and Colorectal Cancer: a Pooled A, VITamin D and omegA-3 triaL (VITAL), The Women's Health Study: Addition of New Data to Maximize its Research Impact, The Women's Health Study: Infrastructure Support for Continued Cohort Follow-up, TRIAL OF ASPIRIN AND VITAMIN E IN WOMEN, Effect of Vitamin D and Omega-3 Fatty Acids on Blood Pressure and Hypertension, Women's Health Study: Continued Follow-up, Women's Health Study: Infrastructure support for cohort follow-up, The VITamin D and OmegA-3 TriaL (VITAL)
OpenAlex ID: W2783830924