Work

Progress with covalent small-molecule kinase inhibitors

Year: 2018

Type: review

Abstract: With reduced risk of toxicity and high selectivity, covalent small-molecule kinase inhibitors (CSKIs) have emerged rapidly. Through the lens of structural system pharmacology, here we review this rapid progress by considering design strategies and the challenges and opportunities offered by current CSKIs.

Source: Drug Discovery Today

DOI: 10.1016/j.drudis.2018.01.035

Authors: Zheng Zhao, Philip E. Bourne

Institution: University of Virginia

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,720