Work

TORC1 inhibition enhances immune function and reduces infections in the elderly

Year: 2018

Type: article

Abstract: Treating elderly subjects with two low-dose mTOR inhibitors that selectively block TORC1 led to a decrease in infection rates.

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.aaq1564

Authors: Joan B. Mannick, Melody Morris, Hans-Ulrich P. Hockey, Guglielmo Roma, Martin Beibel, Kenneth Kulmatycki, Mollie Watkins, Tea Shavlakadze, Weihua Zhou, Dean Quinn, David J. Glass, Lloyd B. Klickstein

Institutions: Novartis (Switzerland), Novartis Institutes for BioMedical Research

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Novartis

OpenAlex ID: W2844364183

FWCI: 15.92

Cites: 24

Cited by: 505

Related to: 10