Work

Reply to Edemir: Physiological regulation and single-cell RNA sequencing

Year: 2018

Type: letter

Abstract: Tacitly, Edemir (1) points to an important issue in the interpretation of data from single-cell RNA-sequencing experiments. Any given cell can exist in a variety of regulatory states that are affected both by extracellular signals and the prior history of the cell. Consequently, data from single-cell RNA sequencing, such as carried out in our paper (2), provide only a partial characterization of a given cell type. Workers engaged in large-scale attempts to identify transcriptomes of every cell type in the body (3) would do well to take note of this … [↵][1]1To whom correspondence should be addressed. Email: maurice_burg{at}nih.gov. [1]: #xref-corresp-1-1

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1720333115

Authors: Lihe Chen, Jae Wook Lee, Chung-Lin Chou, Anil V. Nair, Maria A. Battistone, Teodor G. Păunescu, Maria Merkulova, Sylvie Breton, Jill W. Verlander, Susan M. Wall, Dennis Brown, Maurice B. Burg, Mark A. Knepper

Institutions: National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Center, Harvard University, Massachusetts General Hospital, Center for Systems Biology, University of Florida Health, University of Florida, Emory University

Language: English

Topic: Single-cell and spatial transcriptomics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Interaction of NEDD4-2 and Aldosterone in Intercalated Cell Function, Computational Tools for Proteomics

OpenAlex ID: W2784112986

Cites: 12

Cited by: 2

Related to: 10