Work

NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBPα and inflammatory signaling

Year: 2018

Type: article

Abstract: transcription. In addition, NR4A1/3 occupy the regulatory regions of NF-κB-regulated inflammatory cytokines, antagonizing the activation of NF-κB signaling. Taken together, our results reveal a novel coordinate control of HSC quiescence by NR4A1/3 through direct activation of C/EBPα and suppression of activation of NF-κB-driven proliferative inflammatory responses.

Source: Blood

DOI: 10.1182/blood-2017-07-795757

Authors: Pablo R. Freire, Orla M. Conneely

Institution: Baylor College of Medicine

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Dan L. Duncan Cancer Center, Baylor College of Medicine, National Institutes of Health, National Cancer Institute