WITHDRAWN: Effects of clinicopathological factors on prognosis of young patients with breast cancer
Year: 2018
Type: article
Study design: Observational Study
Abstract: // Wen Li 1, 2, * , Guangzhi Ma 2, * , Qiang Wu 2, * , Ya Liu 1 , Xuejuan Liu 1 and Jing Wang 1 1 Department of Thyroid and Breast Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P. R. China 2 Lung Cancer Center, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P. R. China * These authors contributed equally to this work Correspondence to: Jing Wang, email: [email protected] Keywords: young age; breast cancer; prognosis; molecular subtypes; survival Received: July 05, 2017 Accepted: December 30, 2017 Published: January 06, 2018 ABSTRACT Objective: This study aims to analyze the relationship between clinicopathological characteristics and survival in young patients (≤ 35 years old) with breast cancer. Results: Compared with patients aged 30 to 35 years, age of younger patients (≤ 30 years) was an independent predictor for poor disease-free survival (DFS) and overall survival (OS). PR negative status ( p = 0.042), high tumor grade ( p = 0.012), and advanced lymph nodes post-surgery ( p < 0.001) were independent prognostic factors of DFS, while PR negative status ( p = 0.003) and advanced lymph nodes post-surgery ( p = 0.002) were both independent prognostic factors of OS. For patients with hormone receptor-positive breast cancer, people with ER+ or PR+ and HER2−/+ status showed poorer prognosis than the other two levels. Risk factor grouping based on the ER, PR, HER2, Ki-67 status, tumor grade, and lymph nodes post-surgery showed that patients in highest score group received the poorest prognosis. Materials and Methods: A total of 173 cases of young breast cancer patients were included in this study. The clinicopathological factors potentially associated with prognosis were evaluated by univariate and multivariate analyses. Furthermore, we categorized patients into different groups to evaluate the prognosis according to hormone receptor status or important risk factors. Conclusions: Patient age, PR status, tumor grade, and lymph nodes post-surgery had clinical value as predictive factors of prognosis. Grading system based on the hormone status or the risk factor grouping may offer a useful approach to assess which subgroups of young breast cancer patients present poorer prognosis.
Source: Oncotarget
Authors: Wen Li, Guangzhi Ma, Qiang Wu, Ya Liu, Xuejuan Liu, Jing Wang
Institution: West China Hospital of Sichuan University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2784247235