Work

Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence

Year: 2018

Type: article

Study design: Observational Study

Abstract: In 785 mother-child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems. We examined prenatal and postnatal effects. For externalizing problems, one prenatal effect was found: i-ePGS at birth associated with higher externalizing problems (ages 7-15) indirectly through lower cognitive function (age 7). For internalizing problems, we identified two effects. For a prenatal effect, i-ePGS at birth associated with higher internalizing symptoms via continuity in i-ePGS at age 7. For a postnatal effect, higher postnatal adversity exposure (birth through age 7) associated with higher internalizing problems (ages 7-15) via higher i-ePGS (age 7). Hence, externalizing problems were related mainly to prenatal effects involving lower cognitive function, whereas internalizing problems appeared related to both prenatal and postnatal effects. The present study supports a link between i-ePGS and child and adolescent mental health.

Source: Development and Psychopathology

DOI: 10.1017/s0954579418000330

Authors: Edward D. Barker, Charlotte A. M. Cecil, Esther Walton, Lotte C. Houtepen, Thomas G. O'Connor, Andrea Danese, Sara R. Jaffee, Sarah K. G. Jensen, Carmine Pariante, Wendy McArdle, Tom R. Gaunt, Caroline L. Relton, Susanna Roberts

Institutions: King's College London, University of Bristol, University of Rochester Medicine, University of Pennsylvania, Harvard University

Language: English

Topic: Child and Adolescent Psychosocial and Emotional Development

Subfield: Clinical Psychology

Field: Psychology

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Wellcome Trust, National Institute for Health and Care Research, University of Bristol, Medical Research Council, Biotechnology and Biological Sciences Research Council, Economic and Social Research Council, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G1192034430, G1415860003, G1446110757, G1605161196, G1955001954, G2291477964, G235045266, G2785358084, How early stress gets under the skin: The role of DNA methylation in the development of youth conduct problems and comorbid symptoms, G2935734355, G317400622, G3233603352, INTERpreting epigenetic signatures in STudies of Early Life Adversity (InterStELA), G3825777449, G3831911591, Accessible resource for integrated epigenomics studies (ARIES), The Avon Longitudinal Study for Parents and Children: An international resource for population genomic and lifecourse epidemiology. Core programme support 2014-2019., G5107313190, NIHR Senior Investigator Award, G5465284040, G5562631338, Accessible resource for integrated epigenomics studies (ARIES), G6119919417, G6689231961, G6751436026, Maternal Prenatal Psychological Distress, Poor Nutrition and Atypical Child Development, G738105237, G7614373100, G7775523268, G8009351043, Epigenetic Pathways to Conduct Problem Trajectories: Early Environmental Risks, G824700880, G8459925867, G8498913516, G8782766175, G9000164307

OpenAlex ID: W2784535730

FWCI: 4.982

Cites: 83

Cited by: 64

Related to: 10