Work

Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer

Year: 2018

Type: review

Abstract: DNA damage response and repair genes (DDR genes) are commonly mutated in bladder cancer. The biological impact of these mutations is an area of intense basic, translational, and clinical interest. As next generation sequencing increases its foothold in the treatment of localized and advanced bladder cancer, the role of DDR genes will continue to evolve. We review the inventory and biology of DDR genes in bladder cancer and describe known and candidate roles for loss of DDR genes to engender therapeutic susceptibilities to various anti-cancer agents.

Source: Bladder Cancer

DOI: 10.3233/blc-170129

Authors: Philip H. Abbosh, Elizabeth R. Plimack

Institutions: Fox Chase Cancer Center, Jefferson Einstein Philadelphia Hospital

Language: English

Topic: Bladder and Urothelial Cancer Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W2785110047

FWCI: 0.667

Cites: 65

Cited by: 26

Related to: 10