Recent Thymic Emigrants and Tregs Expressing CD31 and CD45RA Are Decreased at Day 100 and Prognostic for Chronic GvHD in Children: Results From the Applied Biomarkers of Late Effects (ABLE)/Pediatric Blood and Marrow Transplant Consortium 1202 Study
Year: 2018
Type: article
Abstract: Background: Our group and others (Greinix BBMT 2015) have shown that higher proportions of recent thymic emigrants (RTEs: CD4+CD45RA+CD31+) at d100 are a prognostic biomarker for chronic GvHD in adults. We sought to understand whether RTEs, as well as regulatory T cells (CD4+CD25+CD127Lo) that co-express naïve and recently emigrated markers (CD45RA+CD31+; Treg RTEs) were prognostic at d100 for pediatric cGvHD.
Authors: Geoff D.E. Cuvelier, Eneida R. Nemecek, Justin T. Wahlstrom, Andrew C. Harris, Michael A. Pulsipher, Victor Lewis, Henrique Bittencourt, Sung Won Choi, Carrie L. Kitko, Emi Caywood, Monica Bhatia, Kmberly Kasow, David A. Jacobsohn, Benjamin R. Oshrine, Albert Kheradpour, Sonali Chaudhury, Joseph H. Chewning, Tal Schechter, Allyson Flower, Don W. Coulter, Michael Joyce, Sureyya Savasan, Anna Pawlowska, Gail Megason, David Mitchell, Alexandra Cheerva, Amina Kariminia, Anat Halevy, Kirk R. Schultz
Institutions: CancerCare Manitoba, Oregon Health & Science University, Doernbecher Children's Hospital, University of California, San Francisco, UCSF Benioff Children's Hospital, Primary Children's Hospital, University of Utah, Children's Hospital of Los Angeles, Alberta Children's Hospital, Centre Hospitalier Universitaire Sainte-Justine, Michigan Medicine, Vanderbilt University Medical Center, Alfred I. duPont Hospital for Children, Columbia University Irving Medical Center, Columbia University, University of North Carolina at Chapel Hill, Children's National, Johns Hopkins All Children's Hospital, Loma Linda University Medical Center, Northwestern University, Lurie Children's Hospital, University of Alabama at Birmingham, Hospital for Sick Children, New York Medical College, University of Nebraska Medical Center, Nemours Children’s Clinic, Nemours Children's Clinic, Nemours Children's Clinic, Wayne State University, Children's Hospital of Michigan, City Of Hope National Medical Center, City of Hope, University of Mississippi Medical Center, Montreal Children's Hospital, McGill University Health Centre, University of Louisville, Kosair Children's Hospital, Norton Hospital, University of British Columbia, Child and Family Research Institute, BC Children's Hospital
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2785320952