Year: 2017
Type: dissertation
Abstract: The hypothesis this review tries to verify is whether the vagus nerve stimulation can be a safe and effective therapy to treat depression symptoms. OBJECTIVESThe objectives that this review will try to assess are: Describe why depression is an important disease to study: o Describe the main symptoms of the major depressive disorder.o Describe the prevalence of the major depression disorder nowadays.o Describe the main treatments for the MDD. Describe the main pathophysiological theories of depression:o Determine how an alteration of the monoamine synapsis can promote the appearance of depressive symptoms.o Explain the relationship between the inflammation and the MDD.o Determine the main characteristics of the hypothalamus-pituitary-adrenal axis dysregulation in depressed patients.o Explain how an alteration of the neurotrophic factors be related with MDD. Review the main characteristics and the molecular mechanism of VNS to treat MDD:o Define the main anatomical and physiological characteristics of the vagus nerve.o Explain the main characteristics of the vagus nerve stimulation o Determine the changes that the VNS can produce in the central system and how this changes are produced o Describe how the VNS can regulate the immune system and the inflammation process o Determine the relationship between the control of the inflammatory system by VNS and the treatment of depression by this treatment
Author: Andrea Martínez Martínez
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2785681023