Year: 2018
Type: article
Study design: Observational Study
Abstract: Introduction Medial temporal lobe (MTL) uptake on tau–positron emission tomography (PET) is seen not only in Alzheimer's disease (AD) dementia but also in the aging population. The relationship of these findings to the development of AD dementia needs to be better understood. Methods Tau‐PET with AV‐1451 was performed on 576 cognitively unimpaired (CU) participants aged 50–94 years. The number of CUs with and without abnormal MTL regions and those with or without extra‐MTL abnormalities was determined. Left and right regions were compared within each subject. Results Of CUs, 58% (334/576) had abnormal tau‐PET findings. MTL abnormalities were present in 41% (238/576) of subjects. Discussion MTL tau‐PET signal is often associated with abnormal extra‐MTL tau‐PET signal in CU participants and may represent neurofibrillary tangle development that could identify participants most likely to develop AD dementia. Tau‐PET signal exclusively outside of the MTL is seen in 17% of CU participants and could be the initial findings in participants in different AD dementia pathways. Significant (P < .001) differences in tau–standardized uptake value ratio between sides were noted in 26 of 41 examined brain regions implicating further study of side‐specific deficits.
Institutions: Mayo Clinic, Mayo Clinic in Florida
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,540
Funders: Robert Wood Johnson Foundation, Mayo Clinic, Mayo Foundation for Medical Education and Research, GHR Foundation, Elsie and Marvin Dekelboum Family Foundation, National Institutes of Health, Avid Radiopharmaceuticals, National Institute on Aging, National Institute on Deafness and Other Communication Disorders, National Institute of Neurological Disorders and Stroke
Awards: The role of acetylation in regulating pathophysiology of tau, PIB PET Scanning in Speech and Language Based Dementias, Manipulating tau's posttranslational modifications to block disease progression in vivo, Alzheimers Disease Patient Registry, Evaluating and Extending Our Hypothetical Model of Alzheimer's Biomarkers, G5484535055, Longitudinal Multi-modal Imaging in Progressive Supranuclear Palsy Syndromes, Prevention of Alzheimer's disease in women: risks and benefits of hormone therapy, G6870540333, Brain Aging and Alzheimer's Biomarker Classification Using Amyloid PET, tau PET, and Neurodegeneration on MRI: Developing the ATN system, Longitudinal Imaging Biomarkers of Prodromal DLB, Mayo Alzheimer's Disease Research Center
OpenAlex ID: W2786030143