Work

Structure-guided design of a potent peptide inhibitor targeting the interaction between CRK and ABL kinase

Year: 2018

Type: article

Abstract: biochemical assay demonstrated that PRM-3 inhibits the ABL-dependent phosphorylation of CRK-II more effectively than imatinib. Remarkably, PRM-3 also inhibited the CRK phosphorylation by T315I-ABL kinase, which is resistant to all first- and second-generation tyrosine kinase inhibitors. Our study provides a promising alternative approach to overcome the drug resistance of ABL kinase.

Source: MedChemComm

DOI: 10.1039/c7md00619e

Authors: Qingliang Shen, Veer S. Bhatt, Inna Krieger, James C. Sacchettini, Jae-Hyun Cho

Institution: Texas A&M University

Language: English

Topic: Computational Drug Discovery Methods

Subfield: Computational Theory and Mathematics

Field: Computer Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Texas A and M University