Oral Administration of Zataria multiflora Extract Decreases IL-17 Expression in Perennial Allergic Rhinitis.
Year: 2018
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: BACKGROUND: Rhinitis, which occurs most commonly as allergic rhinitis and affects 20% of the world's population, is a major health care burden causing significant morbidity. Considering the high prevalence of allergic rhinitis and anti-inflammatory effects of thyme, a favorite condiment, we performed a randomized clinical trial to determine whether thyme can relieve allergic rhinitis symptoms and affect the expression of TH17- and T-regulatory cell- (Treg) related cytokines IL-17, TGF-β, FOXP3, and IL-10. METHODS: (ZM) extracts and the control group received placebo for two months. Expression of IL-17, TGF-β, FOXP3, and IL-10 was evaluated in all subjects by real-time PCR before and after intervention. RESULTS: After treatment IL-17 expression was significantly less in the ZM group than in controls (p<0.05), while TGF-β, FOXP3, and IL-10, expression were not significantly changed. CONCLUSION: Given the significant effect of thyme in reducing symptoms of allergic rhinitis and decrease IL-17 gene expression and because allergic rhinitis is a multifactorial disease, the administration of thyme extract along with conventional treatments may benefit allergic rhinitis sufferers.
Source: Europe PMC (PubMed Central)
Institution: Mashhad University of Medical Sciences
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2786326765