Year: 2018
Type: review
Abstract: The primary progressive aphasias are a heterogeneous group of focal 'language-led' dementias that pose substantial challenges for diagnosis and management. Here we present a clinical approach to the progressive aphasias, based on our experience of these disorders and directed at non-specialists. We first outline a framework for assessing language, tailored to the common presentations of progressive aphasia. We then consider the defining features of the canonical progressive nonfluent, semantic and logopenic aphasic syndromes, including 'clinical pearls' that we have found diagnostically useful and neuroanatomical and other key associations of each syndrome. We review potential diagnostic pitfalls and problematic presentations not well captured by conventional classifications and propose a diagnostic 'roadmap'. After outlining principles of management, we conclude with a prospect for future progress in these diseases, emphasising generic information processing deficits and novel pathophysiological biomarkers.
Source: Journal of Neurology
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,790
Funders: Wellcome Trust, Barts Charity, National Brain Appeal, Alzheimer's Society, National Institute for Health and Care Research, Brain Research Trust, University College London, Rosetrees Trust, Wolfson Foundation, Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council
Awards: Better Conversations with Primary Progressive Aphasia (BCPPA): Communication training to keep families together., G1509129543, Created Out of Mind: Shaping perceptions of dementia through art and science, NIHR Senior Investigator Award, Computational PLatform for Assessment of Cognition In Dementia (C-PLACID), Profiling dementias using complex sound: from symptoms to brain networks., The UK GENetic Frontotemporal dementia Initiative (UK GENFI), A next-generation MRI brain imaging platform for dementia research: from microstructure to function, G4247185366, Seeing what they see: compensating for cortical visual dysfunction in Alzheimer's disease, The GENetic Frontotemporal Dementia Initiative (GENFI): a new multi-centre platform for the study of frontotemporal lobar degeneration, G7100066897, G7248478464, G7697514025, NIHR Senior Investigator Award, G8452586996, G8620215749, Developing an evidence base for trials in genetic frontotemporal dementia - measures of disease onset and progression, G942021869
OpenAlex ID: W2786364602