Work

Recent approaches in whole cell pneumococcal vaccine development: a review study.

Year: 2017

Type: review

Abstract: still causes widespread morbidity and mortality. Current vaccines contain free polysaccharides or protein-polysaccharide conjugates, but do not induce protection against serotypes that are not included in the vaccines. Therefore, developing alternative vaccines is of high priority and importance. Several investigators have identified protective antigens common to pneumococci of many or all serotypes. Malley et al. in their study, have recommended unencapsulated whole cells, as an alternative vaccine, a number of such antigens unoccluded by capsule were presented in a native configuration in 2001. This review aimed at presenting this candidate of pneumococcal vaccine and results in an animal model.

Source: PubMed

Authors: Mona Mohammadzadeh, Setareh Mamishi, Babak Pourakbari, Shima Mahmoudi

Institution: Tehran University of Medical Sciences

Language: English

Topic: Pneumonia and Respiratory Infections

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2786486248

FWCI:

Cites: 35

Cited by: 3

Related to: 10