Work

Boosting, Not Breaking: CRISPR Activators Treat Disease Models

Year: 2018

Type: article

Abstract: Genome editing with DNA-targeting tools, such as CRISPR/Cas9, zinc finger proteins, and transcription activator-like effectors, has emerged as an exciting new approach to gene and cell therapy.1 Genome editing technologies have become most well-known through the use of these tools as engineered DNA-targeting nucleases that create breaks in the genomic DNA to create changes to gene sequences. This includes repairing genes that are mutated in inherited disorders or knocking out genes that facilitate unwanted functions, such as viral infection.

Source: Molecular Therapy

DOI: 10.1016/j.ymthe.2018.01.004

Authors: Matthew Gemberling, Charles A. Gersbach

Institution: Duke University

Language: English

Topic: CRISPR and Genetic Engineering

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500