Year: 2017
Type: article
Abstract: Widespread alternative polyadenylation (APA) occurs during enhanced cellular proliferation and transformation. Recently, we demonstrated that CFIm25-mediated 3' UTR shortening through APA promotes glioblastoma tumor growth in vitro and in vivo, further underscoring its significance to tumorigenesis. Here, we report The Cancer 3' UTR Atlas (TC3A), a comprehensive resource of APA usage for 10,537 tumors across 32 cancer types. These APA events represent potentially novel prognostic biomarkers and may uncover novel mechanisms for the regulation of cancer driver genes. TC3A is built on top of the now de facto standard cBioPortal. Therefore, the large community of existing cBioPortal users and clinical researchers will find TC3A familiar and immediately usable. TC3A is currently fully functional and freely available at http://tc3a.org.
Source: Nucleic Acids Research
DOI: 10.1093/nar/gkx892
Authors: Xin Feng, Lei Li, Eric J Wagner, Wei Li
Language: English
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,992
Awards: Computational and Experimental Modeling of Epigenetic DNA Methylation, The Role of Alternative Polyadenylation in Glioblastoma Tumor Progression, Broad Shortening of 3' UTRs in Human Cancers: Methods, Target Genes and Functional Consequences, Computational and Experimental Modeling of Alternative Polyadenylation
OpenAlex ID: W2786594082