Work

Role of Astrocytic Mitochondria in Limiting Ischemic Brain Injury?

Year: 2018

Type: review

Abstract: Until recently, astrocyte processes were thought to be too small to contain mitochondria. However, it is now clear that mitochondria are found throughout fine astrocyte processes and are mobile with neuronal activity resulting in positioning near synapses. In this review, we discuss evidence that astrocytic mitochondria confer selective resiliency to astrocytes during ischemic insults and the functional significance of these mitochondria for normal brain function.

Source: Physiology

DOI: 10.1152/physiol.00038.2017

Authors: Evelyn K. Shih, Michael B. Robinson

Institutions: Children's Hospital of Philadelphia, University of Pennsylvania

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Children's Hospital of Philadelphia, National Institutes of Health, National Institute of Neurological Disorders and Stroke