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Chemical Profile and Anti-inflammatory Activity of Total Flavonoids from Glycyrrhiza Uralensis Fisch.

Year: 2018

Type: article

Abstract: edema assays demonstrated that the TFF possesses significant dose-dependent anti-inflammatory activity, similar to that of indomethacin at a dose of 500 mg/kg. In rat paws with carrageenan, treatment with TFF (500 and 250 mg/kg) markedly inhibited the expression of IL-1β and iNOS. TFF at all doses noticeably decreased levels of NO and MDA at the site of inflammation, while only i.g. TFF at a dose of 500 mg/kg significantly decreased TNF-α levels in the carrageenan-injected paws. In addition, an increase in SOD activity was induced by TFF at all doses. These results revealed that TFF exhibited significant anti-inflammatory activity in acute inflammatory models.

Source: Europe PMC (PubMed Central)

Authors: Lei Yin, Enshuang Guan, Yuanbin Zhang, Zhiheng Shu, Bing Wang, Xiuli Wu, Jing Chen, Jingxia Liu, Xueyan Fu, Weihong Sun, Meifeng Liu

Institutions: Ningxia Medical University, Ningxia Medical University General Hospital, South China University of Technology

Language: English

Topic: Pharmacological Effects of Natural Compounds

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2787468498

FWCI: 4.049

Cites: 37

Cited by: 39

Related to: 10