Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer’s disease.
Year: 2018
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To evaluate whether a history of traumatic brain injury (TBI) with reported loss of consciousness (LOC) is a risk factor for earlier onset of Alzheimer's disease (AD) in an autopsy-confirmed sample. METHOD: Data from 2,133 participants with autopsy-confirmed AD (i.e., at least Braak neurofibrillary tangle stages III to VI and CERAD neuritic plaque score moderate to frequent) were obtained from the National Alzheimer's Coordinating Center (NACC). Participants were categorized by presence/absence of self-reported remote (i.e., >1 year prior to their first Alzheimer's Disease Center visit) history of TBI with LOC (TBI+ vs. TBI-). Analyses of Covariance (ANCOVA) controlling for sex, education, and race compared groups on clinician-estimated age of symptom onset and age of diagnosis. RESULTS: Average age of onset was 2.34 years earlier (p = .01) for the TBI+ group (n = 194) versus the TBI- group (n = 1900). Dementia was diagnosed on average 2.83 years earlier (p = .002) in the TBI+ group (n = 197) versus the TBI- group (n = 1936). Using more stringent neuropathological criteria (i.e., Braak stages V-VI and CERAD frequent), both age of AD onset and diagnosis were 3.6 years earlier in the TBI+ group (both p's < .001). CONCLUSIONS: History of TBI with reported LOC appears to be a risk factor for earlier AD onset. This is the first study to use autopsy-confirmed cases, supporting previous investigations that used clinical criteria for the diagnosis of AD. Further investigation as to possible underlying mechanisms of association is needed. (PsycINFO Database Record
Source: Neuropsychology
DOI: 10.1037/neu0000423
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G1039114937, G1251691413, Michigan Alzheimer's Disease Core Center, UC Davis Alzheimer's Disease Core Center, Indiana Alzheimer Disease Center, G137034508, G1573543821, G16257404, Wake Forest Alzheimer's Disease Core Center, G1938936581, G2048183384, University of Kentucky Alzheimer's Disease Core Center, Neurobiology of Alzheimer's Disease and Aging, G2610857296, Alzheimer's Disease Research Center, National Alzheimer's Coordinating Center, UCSD Alzheimer's Disease Research Center P50, Alzheimer's Disease Research Center, G3556322637, G3571628160, G3660653841, G3837026747, Alzheimer's Disease Core Center, G4309566773, The Alzheimer's Disease Research Center at the University of California, Irvine, G4507852234, Stanford Alzheimer's Disease Research Center, Oregon Alzheimer's Disease Center, Rush Alzheimer's Disease Core Center, G5134330843, G5913806709, Alzheimer's Disease Core Center, G5943354006, G6148316848, Alzheimer's Disease Research Center - Overall, G6312586787, Wisconsin Alzheimer's Disease Research Center, University of Kansas Alzheimer's Disease Core Centers, G6750938764, Alzheimer's Disease Research Center, G6957921728, Alzheimer Disease Research Center, Yale Alzheimer Disease Research Center, Arizona Alzheimer's Disease Core Center, Johns Hopkins Alzheimer's Disease Research Center, G7305642361, Boston University Alzheimer's Disease Center, Alzheimer's Disease Research Center, Massachusetts Alzheimer's Disease Research Center, G7809532791, Alzheimer's Disease Core Center, G7929924427, Emory Alzheimer's Disease Center, G8097559139, University of Florida - Mt. Sinai Medical Center AD Research Center, G848183251, G8491490186, G8691269599, New Approaches to Dementia Heterogeneity, Mayo Alzheimer's Disease Research Center
OpenAlex ID: W2787545029