Untargeted metabolomics of childhood asthma exacerbations from retrospectively collected serum samples
Year: 2017
Type: dissertation
Abstract: Asthma is a common chronic inflammatory disease of the airways, affecting 360 million people globally.It is characterised by chronic inflammation, recurrent episodes of bronchoconstriction and mucosal hypersecretion.Symptoms include chest tightness, shortness of breath, coughing and wheezing.Oral corticosteroids used for the treatment of asthma have adverse effects, including bone mineralisation and adrenal suppression.Not all children with acute asthma-like symptoms will have persistent asthma in the future.This is particularly common at a pre-school age.This persistence is only known retrospectively.Identifying children early in their disease course can better direct treatment.Additionally, further understanding of the underlying disease mechanisms can direct novel therapies.
Author: Kevin Mendez
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: Murdoch University
OpenAlex ID: W2788030393