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Chiral Drug Analysis in Forensic Chemistry: An Overview

Year: 2018
Type: article
Abstract: Many substances of forensic interest are chiral and available either as racemates or pure enantiomers. Application of chiral analysis in biological samples can be useful for the determination of legal or illicit drugs consumption or interpretation of unexpected toxicological effects. Chiral substances can also be found in environmental samples and revealed to be useful for determination of community drug usage (sewage epidemiology), identification of illicit drug manufacturing locations, illegal discharge of sewage and in environmental risk assessment. Thus, the purpose of this paper is to provide an overview of the application of chiral analysis in biological and environmental samples and their relevance in the forensic field. Most frequently analytical methods used to quantify the enantiomers are liquid and gas chromatography using both indirect, with enantiomerically pure derivatizing reagents, and direct methods recurring to chiral stationary phases.
Source: Molecules
Language: English
Subfield: Spectroscopy
Field: Chemistry
Open Access status: gold
Estimated APC paid: $3,258
OpenAlex ID: W2788218532
FWCI: 3.908
Cites: 162
Cited by: 89
Related to: 10