Biochemical Status of Vitamin D and Related Biomarkers as Predictors of Severe Influenza Infection in Children
Year: 2016
Type: dissertation
Study design: Observational Study
Abstract: Eighty-two influenza-positive children were recruited prospectively from the inpatient units of four Canadian pediatric referral centers. Serum 25-hydroxyvitamin D [25(OH)D] levels were inversely associated with influenza severity (B = -0.43, p-value = 0.03). Participants whose serum 25(OH)D levels fell below 50 nmol/L had significantly higher maximum Composite Severity Index ÂŽ (maxCSI) scores than those with serum levels â Ľ50 nmol/L (medians of 56 vs. 37, p-value = 0.01). Serum LL-37 levels were also found to be inversely associated with maxCSI scores among participants (B = -0.78, p-value = 0.03). Only serum 25(OH)D levels remained a significant predictor of influenza severity when incorporated into a multivariable model controlling for patient sex, age, zBMI, maternal education, vaccination status and influenza type (B = -0.50, SE = 0.20, p-value = 0.04). Results from this study indicate that serum 25(OH)D levels
Source: TSpace (University of Toronto)
Author: Eleanor Jane Reid
Language: English
Topic: Vitamin D Research Studies
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2788290676