Impact of Gender on In-hospital Mortality in Patients with Acute Myocardial Infarction in Nagasaki
Year: 2018
Type: article
Study design: Observational Study
Abstract: Acute myocardial infarction (AMI) is one of the leading causes of death in Japan. Immediate reperfusion therapy, including coronary intervention, improves patient prognosis. Despite this, females are said to be more prone to poor prognosis. A regional \nAMI registry in Nagasaki prefecture has been instituted recently that will evaluate whether female gender might predict short-term \nin-hospital death. Seventeen regional AMI centers enrolled all AMI patients from September 2014 through March 2016. A propensity score (PS) was derived using logistic regression to model the probability of females as a total function of the potential confounding covariates. Two types of PS techniques were used: PS matching and PS stratification. The consistency of in-hospital\ndeath was determined between PS matched patients of both genders. Based on PS, patients were ranked and stratified into\nfive groups for the PS stratification. Out of 996 patients, 67 (6.7%) died during hospitalization: 31 (10.4%) out of 298 females and 36 (5.2%) out of 698 males (p < 0.0025). The proportion of cardiac and non-cardiac related death was almost same between\ngenders (25 and 6 in female, 29 and 7 in male, respectively). Among 196 PS matched patients, there was a consistency between genders regarding in-hospital deaths (McNemar test, p = 0.6698). The 717 propensity scored patients had no significant differences between genders among propensity quintiles (Cochran-Mantel-Heanszel test, p = 0.7117). We found that gender alone is not an indicator of short-term in-hospital death in acute myocardial infarction patients.
Authors: Koide, Yuji, Koga, Seiji, Muroya, Takahiro, Nakashima, Hiroshi, Ishizaki, Masahiko, Ashizawa, Naoto, Sakai, Hideaki, Yoshitake, Takatoshi, Hata, Shiro, Kizaki, Yoshihisa, Yamasa, Toshihiko, Oku, Koji, Tanioka, Yoshito, Yamaguchi, Kenji, Izumikawa, Takuya, Fukui, Jun, Fukahori, Masami, Negishi, Kota, Yoshida, Kazuroh, Ikeda, Satoshi, Kawano, Hiroaki, Maemura, Koji
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2788804058