Work

Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model

Year: 2018

Type: article

Abstract: ABSTRACT The manner in which zebrafish are fed may have important impacts on the behavior of disease models. We examined the effect of different feeding regimens on the rate of overt melanoma tumor onset in a p53/BRAF-dependent model, a commonly used read-out in this and many other cancer models. We demonstrate that increased feeding leads to more rapid melanoma onset. The ability to modulate overt tumor onset rates with this regimen indicates additional flexibility to ‘tune’ the system to more quickly generate tumors for study and to begin to address questions related to cancer metabolism using the zebrafish model.

Source: Biology Open

DOI: 10.1242/bio.030726

Authors: Vadim Grigura, Megan Barbier, Anna P. Zarov, Charles K. Kaufman

Institution: Washington University in St. Louis

Language: English

Topic: Zebrafish Biomedical Research Applications

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,995