PDGFRB mutation and tyrosine kinase inhibitor resistance in Ph-like acute lymphoblastic leukemia

Year: 2018

Type: article

Abstract: Key Points AGGF1-PDGFRB is a novel oncogenic fusion gene in Ph-like ALL. Genomic profiling and functional studies identified a novel PDGFRB mutation directly related to TKI resistance.

Source: Blood

DOI: 10.1182/blood-2017-11-817510

Authors: Yingchi Zhang, Yufeng Gao, Hui Zhang, Jingliao Zhang, Fuhong He, Aleš Hnízda, Maoxiang Qian, Xiaoming Liu, Yoshihiro Gocho, Ching-Hon Pui, Tao Cheng, Qianfei Wang, Jun J. Yang, Xiaofan Zhu, Xin Liu

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Hematology & Blood Diseases Hospital, State Key Laboratory of Experimental Hematology, Chinese Academy of Sciences, Beijing Institute of Genomics, University of Chinese Academy of Sciences, St. Jude Children's Research Hospital, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Czech Academy of Sciences, Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry

Language: English

Topic: Acute Lymphoblastic Leukemia research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: American Lebanese Syrian Associated Charities, National Natural Science Foundation of China, Grantová Agentura České Republiky, Chinese Academy of Sciences, Government of Jiangsu Province, Youth Innovation Promotion Association of the Chinese Academy of Sciences, Tianjin Science and Technology Committee, Peking Union Medical College, National Institutes of Health, Youth Innovation Promotion Association, National Cancer Institute, National Institute of General Medical Sciences

OpenAlex ID: W2789537253