Work

Pannexin Channel Inhibition

Year: 2018

Type: editorial

Abstract: More than 50 years after spironolactone has come on the market its mechanism of action continues to expand. In this issue of Circulation Research, Good et al. document the discovery that spironolactone is not only an inhibitor of the mineralocorticoid receptor, but also inhibits pannexin 1 channels.

Source: Circulation Research

DOI: 10.1161/circresaha.118.312566

Author: Sabine Huke

Institutions: University of Alabama at Birmingham, UAB Medicine

Language: English

Topic: Adenosine and Purinergic Signaling

Subfield: Physiology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Impact Fund, University of Alabama at Birmingham, National Institutes of Health, National Heart, Lung, and Blood Institute