Salicylic Acid‐Based Polymeric Contrast Agents for Molecular Magnetic Resonance Imaging of Prostate Cancer
Year: 2018
Type: article
Abstract: Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) is an innovative molecular imaging technique in which contrast agents are labeled by saturating their exchangeable proton spins by radio‐frequency irradiation. Salicylic acid and its analogues are a promising class of highly sensitive, diamagnetic CEST agents. Herein, polymeric agents grafted with salicylic acid moieties and a known high‐affinity ligand targeting prostate‐specific membrane antigen in approximately 10:1 molar ratio were synthesized to provide sufficient MRI sensitivity and receptor specificity. The proton‐exchange properties of the contrast agent in solution and in an experimental murine model are reported to demonstrate the feasibility of receptor‐targeted CEST MRI of prostate cancer. Furthermore, the CEST imaging data were validated with an 111 In‐labeled analogue of the agent by in vivo single photon emission computed tomographic imaging and tissue biodistribution studies.
Source: Chemistry - A European Journal
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
Awards: Multi-Color Exchange Transfer Imaging of Drug Delivery Nanocarriers, Small Molecule PSMA-Targeted Alpha Therapy, Novel approaches for CEST labeling, detection, quantification and translation, PSMA-based MR Imaging and Therapy of Prostate Cancer, Prostate Specific Membrane Antigen Targeted Photoacoustic Imaging for Prostate Cancer, Center of Cancer Nanotechnology Excellence at Johns Hopkins, Enhanced imaging and treatment of aggressive subtypes of prostate cancer, Resource for Molecular Imaging Agents in Precision Medicine, In vivo Molecular MR Imaging of Inflammation using NSAIDs as CEST agents
OpenAlex ID: W2789700660