Year: 2017
Type: review
Abstract: Species of Scedosporium and Lomentospora are considered as emerging opportunists, affecting immunosuppressed and otherwise debilitated patients, although classically they are known from causing trauma-associated infections in healthy individuals. Clinical manifestations range from local infection to pulmonary colonization and severe invasive disease, in which mortality rates may be over 80%. These unacceptably high rates are due to the clinical status of patients, diagnostic difficulties, and to intrinsic antifungal resistance of these fungi. In consequence, several consortia have been founded to increase research efforts on these orphan fungi. The current review presents recent findings and summarizes the most relevant points, including the Scedosporium/Lomentospora taxonomy, environmental distribution, epidemiology, pathology, virulence factors, immunology, diagnostic methods, and therapeutic strategies.
Source: Medical Mycology
DOI: 10.1093/mmy/myx113
Authors: Andoni Ramirez-Garcia, Aize Pellon, Aitor Rementeria, Idoia Buldain, Eliana Barreto-Bergter, Rodrigo Rollin-Pinheiro, Jardel Vieira de Meirelles, Mariana Ingrid D S Xisto, Stephane Ranque, Vladimir Havlicek, Patrick Vandeputte, Yohann Le Govic, Jean-Philippe Bouchara, Sandrine Giraud, Sharon Chen, Johannes Rainer, Ana Alastruey-Izquierdo, Maria Teresa Martin-Gomez, Leyre M López-Soria, Javier Peman, Carsten Schwarz, Anne Bernhardt, Kathrin Tintelnot, Javier Capilla, Adela Martin-Vicente, Jose Cano-Lira, Markus Nagl, Michaela Lackner, Laszlo Irinyi, Wieland Meyer, Sybren de Hoog, Fernando L Hernando
Institutions: University of the Basque Country, Universidade Federal do Rio de Janeiro, Assistance Publique Hôpitaux de Marseille, Hôpital de la Timone, Czech Academy of Sciences, Czech Academy of Sciences, Institute of Microbiology, Centre Hospitalier Universitaire d'Angers, Université d'Angers, The University of Sydney, Westmead Hospital, Universität Innsbruck, Instituto de Salud Carlos III, Centro Nacional de Microbiologia, Vall d'Hebron Hospital Universitari, Hospital de Cruces, Hospital Universitari i Politècnic La Fe, Charité – Universitätsmedizin Berlin, Robert Koch Institute, Institut de Recerca Biomèdica Catalunya Sud, Universitat Rovira i Virgili, University of Tennessee Health Science Center, Innsbruck Medical University, Westmead Institute for Medical Research, Westerdijk Fungal Biodiversity Institute
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2789742163