Identification of Functional Food Factors as β2-Adrenergic Receptor Agonists and Their Potential Roles in Skeletal Muscle
Year: 2018
Type: article
Abstract: Maintaining skeletal muscle functions by controlling muscle metabolism is of utmost importance. β2-Adrenergic receptor (β2-AR), which is expressed in skeletal muscle, is a member of the G-protein-coupled receptor family that plays a critical role in the maintenance of muscle mass. In the present study, using luciferase reporter assays in β2-AR-expressing HEK293 cells, we discovered several food factors that exhibited agonistic activity at mouse or human β2-AR. Osthole, gramine, and hordenine were identified as both mouse and human β2-AR agonists, whereas berberine was identified as a mouse β2-AR agonist only. Additionally, intramuscular injection of gramine or hordenine in mice facilitated gene expression of several cAMP response element binding protein targets, which is thought to result in increased skeletal muscle protein synthesis. This study provides evidence that several food factors might exert potential health effects on skeletal muscle by enhancing cAMP signaling through the activation of β2-AR.
DOI: 10.3177/jnsv.64.68
Authors: Miho CHIKAZAWA, Ryuichiro SATO
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
Awards: Analysis on molecular nutritional functions of bile acids as a feeding signal, and regulation of metabolic response to feeding by food factors, G2186239577, G2576085165, Prevention of sarcopenia by functional food factors through G protein-coupled receptors., G5494555244, G7266362255, G7879866177, G8115714131
OpenAlex ID: W2789966694