Work

Cell adhesion and matricellular support by astrocytes of the tripartite synapse

Year: 2018

Type: review

Abstract: Astrocytes contribute to the formation, function, and plasticity of synapses. Their processes enwrap the neuronal components of the tripartite synapse, and due to this close interaction they are perfectly positioned to modulate neuronal communication. The interaction between astrocytes and synapses is facilitated by cell adhesion molecules and matricellular proteins, which have been implicated in the formation and functioning of tripartite synapses. The importance of such neuron-astrocyte integration at the synapse is underscored by the emerging role of astrocyte dysfunction in synaptic pathologies such as autism and schizophrenia. Here we review astrocyte-expressed cell adhesion molecules and matricellular molecules that play a role in integration of neurons and astrocytes within the tripartite synapse.

Source: Progress in Neurobiology

DOI: 10.1016/j.pneurobio.2018.02.002

Authors: Anne E.J. Hillen, J. Peter H. Burbach, Elly M. Hol

Institutions: University Medical Center Utrecht, Amsterdam UMC Location Vrije Universiteit Amsterdam, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, University of Amsterdam

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,190