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Low Amphiregulin Expression in Intestinal Biopsies of Patients with Acute Graft-Versus-Host Disease

Year: 2018
Type: article
Abstract: Background: Amphiregulin (AREG), a weak epidermal growth factor receptor (EGFR) agonist associated with unresolved damage, is elevated, while epidermal growth factor (EGF, a strong EGFR agonist) is low, in the blood of patients with severe acute graft-versus-host disease (aGVHD). However, the tissue expression of these EGFR ligands in human aGVHD target organs, and their association with clinical outcomes, is not yet known.
DOI: 10.1016/j.bbmt.2017.12.142
Authors: Khalid Amin, Yaqoob Usman, Brittney Schultz, Byron Vaughn, Justin Howard, Alexander Khoruts, Todd E. Defor, Colleen Forster, Armin Rashidi, Daniel J. Weisdorf, Margaret L. MacMillan, Bruce R. Blazar, Angela Mortari, Shernan G. Holtan
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2790051101
FWCI: 0.538
Cites:
Cited by: 3
Related to: 10