Bioinks for 3D bioprinting: an overview
Year: 2018
Type: review
Abstract: Bioprinting is an emerging technology with various applications in making functional tissue constructs to replace injured or diseased tissues. It is a relatively new approach that provides high reproducibility and precise control over the fabricated constructs in an automated manner, potentially enabling high-throughput production. During the bioprinting process, a solution of a biomaterial or a mixture of several biomaterials in the hydrogel form, usually encapsulating the desired cell types, termed the bioink, is used for creating tissue constructs. This bioink can be cross-linked or stabilized during or immediately after bioprinting to generate the final shape, structure, and architecture of the designed construct. Bioinks may be made from natural or synthetic biomaterials alone, or a combination of the two as hybrid materials. In certain cases, cell aggregates without any additional biomaterials can also be adopted for use as a bioink for bioprinting processes. An ideal bioink should possess proper mechanical, rheological, and biological properties of the target tissues, which are essential to ensure correct functionality of the bioprinted tissues and organs. In this review, we provide an in-depth discussion of the different bioinks currently employed for bioprinting, and outline some future perspectives in their further development.
Source: Biomaterials Science
DOI: 10.1039/c7bm00765e
Institutions: Brigham and Women's Hospital, Harvard University, Harvard–MIT Division of Health Sciences and Technology, Biruni University, Massachusetts Institute of Technology, Wyss Institute for Biologically Inspired Engineering, California NanoSystems Institute, University of California, Los Angeles, King Abdulaziz University, Konkuk University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Funders: Science and Technology Commission of Shanghai Municipality, Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, National Institutes of Health, National Heart, Lung, and Blood Institute, Office of Naval Research, National Cancer Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Biomedical Imaging and Bioengineering
Awards: Recapitulating Ductal Carcinoma on a Chip for Personalized Breast Cancer Therapy, Engineering a naturally derived and highly adhesive surgical sealant, G2123091484, Targeted chemotherapy delivery and capture, G288878142, High-Throughput Microenvironment Regulation for Chondrogenesis, Hemorrhage control in the irreversible anticoagulated patient, Whitlockite nanoparticles for inducing bone regeneration, Catheter guided endovascular electric field ablation for thrombosis therapy., Rapid 3D bioprinting of biomimetic vascularized tissue constructs, Recapitulating Ductal Carcinoma on a Chip for Personalized Breast Cancer Therapy, Microengineered Osteons for Bone Tissue Engineering, Engineering personalized micro-tumor ecosystems, G6998073256, G9000249555
OpenAlex ID: W2790281145