Work

Sclerotic Chronic Graft-Versus-Host Disease Severity Can be Assessed via Biomechanical Properties of Skin

Year: 2018

Type: article

Abstract: Background: A major barrier in the diagnosis of chronic graft-versus-host disease (cGVHD) is lack of reliable, quantitative assessment methods. Skin sclerosis is a common manifestation resulting in significant morbidity. All existing scales to monitor sclerosis, including the NIH skin score, are subjective, suffer low reproducibility, and provide only coarse grading ability. These disadvantages limit the ability to accurately reflect changes in disease progression or treatment response. We propose a noninvasive approach to directly measure biomechanical properties of skin.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2017.12.158