Novel Intrapolymerization Doped Manganese‐Eumelanin Coordination Nanocomposites with Ultrahigh Relaxivity and Their Application in Tumor Theranostics

Year: 2018

Type: article

Abstract: While magnetic resonance imaging contrast agents have potential in noninvasive image‐guided tumor treatment, further developments are needed to increase contrast, biodegradability, and safety. Here, novel engineered manganese‐eumelanin coordination nanocomposites (MnEMNPs) are developed via a facile one‐pot intrapolymerization doping (IPD) approach in aqueous solution, through simple chemical oxidation–polymerization of the 3,4‐dihydroxy‐DL‐phenylalanine precursor with potassium permanganate serving as the Mn source and an oxidant. The resulting MnEMNPs possess ultrahigh longitudinal relaxivity (r1 value up to 60.8 mM−1 s−1 at 1.5 T) attributed to the high manganese doping efficiency (>10%) and geometrically confined conformation. Due to their high manganese chelation stability, excellent biocompatibility, and strong near‐infrared absorption, high‐performance longitudinal‐transverse (T1‐T2) dual‐modal magnetic resonance/photoacoustic imaging and photothermal tumor ablation are achieved. Furthermore, the hydrogen peroxide‐triggered decomposition behavior of MnEMNPs circumvents the poor biodegradation issue of many nanomaterials. This facile, convenient, economical, and efficient IPD strategy will open up new avenues for the development of high‐performance multifunctional theranostic nanoplatforms in bionanomedicine.

Source: Advanced Science

DOI: 10.1002/advs.201800032

Authors: Heng Liu, Chengchao Chu, Yu Liu, Xin Pang, Yayun Wu, Zijian Zhou, Pengfei Zhang, Weiguo Zhang, Gang Liu, Xiaoyuan Chen

Institutions: Army Medical University, Xiamen University, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Southwest Hospital, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering, State Key Laboratory of Cell Stress Biology

Language: English

Topic: Nanoplatforms for cancer theranostics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,730

Funders: National Natural Science Foundation of China, Natural Science Foundation of Fujian Province, Third Military Medical University, Major State Basic Research Development Program of China, Program for New Century Excellent Talents in University, Fundamental Research Funds for the Central Universities

OpenAlex ID: W2790328782