Work

HLA-Class I and II Antigens are Expressed in CD34+ Cells: Implications for HLA Mismatched Bone Marrow Transplantation (BMT)

Year: 2018

Type: article

Abstract: Recipient's preformed donor specific antibodies (DSA) directed at mismatched HLA antigens are associated with impaired engraftment of allogeneic BMT. The mechanism of DSA-mediated primary graft failure (PGF) likely involves both complement-mediated and antibody-dependent-cell-mediated lysis of hematopoietic stem and progenitor cells and other cell populations needed for engraftment. The strength of these responses is in part determined by the level of circulating DSA at the time of infusion and by the density of HLA antigens expressed on the cell surface.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2017.12.431

Authors: Maria P. Bettinotti, Donna P. Lucas, Gabriel Ghiaur, Annette M. Jackson, Douglas E. Gladstone

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Sidney Kimmel Comprehensive Cancer Center

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650