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Central Line–Associated Mucor velutinosus Bloodstream Infection in an Immunocompetent Pediatric Patient

Year: 2017

Type: article

Abstract: We report here the isolation of Mucor velutinosus from multiple blood cultures performed on samples from Broviac catheters and culture of a Broviac insertion-site wound sample from a 6-year-old boy with a history of intestinal failure secondary to chronic intestinal pseudo-obstruction, parenteral nutrition, and jejunostomy tube dependence. Examination of a slide from the culture revealed the presence of wide nonseptate hyphae with sporangiophores, columella, and chlamydospores. The fungal isolate was sent to the National Institutes of Health for further evaluation and was identified as Mucor velutinosus by matrix-assisted laser desorption ionization-time-of-flight mass spectrometry and genomic sequencing. The patient was treated successfully with intravenous amphotericin B and prompt removal of his central line. To the best of our knowledge, this is the first case of M velutinosus bloodstream infection in a child without cancer.

Source: Journal of the Pediatric Infectious Diseases Society

DOI: 10.1093/jpids/pix108

Authors: Madan Kumar, Barbara Jantausch, Clarivet Torres, Joseph Campos, Adrian Zelazny

Institutions: Children's National, National Institutes of Health, National Institutes of Health Clinical Center

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2790340849

FWCI: 0.632

Cites: 7

Cited by: 10

Related to: 10