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MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice

Year: 2018
Type: article
Abstract: Significance Mixed chimerism has shown good potential to cure some autoimmune diseases and prevent tissue rejection. It is known that MHC-mismatched but not -matched mixed chimerism effectively tolerizes autoreactive T cells, even those noncross-reactive T cells that do not directly recognize donor-type antigen presenting cells [i.e., dendritic cells (DCs)]. How this is accomplished remains unknown. These studies have shown that tolerizing peripheral residual host-type noncross-reactive autoreactive T cells requires engraftment of donor-type DCs and involves a host-type DC-mediated increase in donor-type Treg cells, which associates with restoration of tolerogenic features of host-type plasmacytoid DCs and expansion of host-type Treg cells. This study suggests a previously unrecognized tolerance network among donor- and host-type DCs and Treg cells in MHC-mismatched mixed chimeras.
DOI: 10.1073/pnas.1720169115
Authors: Mingfeng Zhang, Jeremy J. Racine, Qing Lin, Yuqing Liu, Shanshan Tang, Qi Qin, Tong Qi, Arthur D. Riggs, Defu Zeng
Institutions: City Of Hope National Medical Center, City of Hope, Beckman Research Institute, Fujian University of Traditional Chinese Medicine, Army Medical University, Xinqiao Hospital, China Pharmaceutical University, State Key Laboratory of Natural Medicine
Language: English
Subfield: Immunology
Open Access status: hybrid
OpenAlex ID: W2790459236
FWCI: 0.644
Cites: 81
Cited by: 11
Related to: 10